| 1. Ronde | 14.08.2021 | RWD Molenbeek | - | Royal Excel Mouscron | 3:1 | ||||
| 2. Ronde | 21.08.2021 | Royal Excel Mouscron | - | Lommel SK | 0:1 | ||||
| 6. Ronde | 26.09.2021 | Royal Excel Mouscron | - | KVC Westerlo | 1:2 |  |
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| 7. Ronde | 02.10.2021 | Lierse Kempenzonen | - | Royal Excel Mouscron | 2:2 | ||||
| 8. Ronde | 17.10.2021 | Lommel SK | - | Royal Excel Mouscron | 3:0 | |
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| 9. Ronde | 22.10.2021 | Royal Excel Mouscron | - | RWD Molenbeek | 1:1 | |
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| 11. Ronde | 06.11.2021 | Royal Excel Mouscron | - | SK Deinze | 2:0 | ||||
| 27. Ronde | 08.04.2022 | Royal Excel Mouscron | - | KVC Westerlo | 2:6 | ||||
| 28. Ronde | 17.04.2022 | Waasland-Beveren | - | Royal Excel Mouscron | 2:0 | |
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