| 3. Ronde | 19.02.2022 | Cerro Porteño | - | Guaraní | 2:0 |  |
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| 6. Ronde | 13.03.2022 | Cerro Porteño | - | Club Olimpia | 0:2 | ||||
| 7. Ronde | 20.03.2022 | Resistencia SC | - | Cerro Porteño | 0:3 | ||||
| 9. Ronde | 10.04.2022 | General Caballero DJLM | - | Cerro Porteño | 0:0 | ||||
| 12. Ronde | 24.04.2022 | Sportivo Ameliano | - | Cerro Porteño | 0:1 | ||||
| 13. Ronde | 01.05.2022 | Cerro Porteño | - | Club Nacional | 1:0 | ||||
| 15. Ronde | 12.05.2022 | Cerro Porteño | - | Guaireña FC | 0:0 | ||||
| 17. Ronde | 22.05.2022 | Club Olimpia | - | Cerro Porteño | 0:4 |
Paraguay