| 2. Ronde | 29.08.2021 | US Colomiers [A-jun] | - | Toulouse FC [A-jun] | 1:1 |  |
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| 3. Ronde | 05.09.2021 | FC Istres [A-jun] | - | US Colomiers [A-jun] | 1:1 | ||||
| 8. Ronde | 10.10.2021 | Nîmes Olympique [A-jun] | - | US Colomiers [A-jun] | 1:0 | ||||
| 9. Ronde | 17.10.2021 | US Colomiers [A-jun] | - | Montpellier HSC [A-jun] | 1:0 | ||||
| 12. Ronde | 21.11.2021 | Olympique Marseille [A-jun] | - | US Colomiers [A-jun] | 2:0 | ||||
| 13. Ronde | 28.11.2021 | US Colomiers [A-jun] | - | AS Cannes [A-jun] | 2:1 | ||||
| 14. Ronde | 05.12.2021 | Toulouse FC [A-jun] | - | US Colomiers [A-jun] | 2:0 | ||||
| 16. Ronde | 23.01.2022 | Pieve di Lota [A-jun] | - | US Colomiers [A-jun] | 0:3 | ||||
| 15. Ronde | 30.01.2022 | US Colomiers [A-jun] | - | FC Istres [A-jun] | 1:0 | ||||
| 17. Ronde | 06.02.2022 | US Colomiers [A-jun] | - | AS Monaco [A-jun] | 1:1 | ||||
| 18. Ronde | 13.02.2022 | US Colomiers [A-jun] | - | AS Saint-Étienne [A-jun] | 0:0 |
Frankrijk