| 1. Ronde | 16.07.2021 | NK Osijek | - | HNK Šibenik | 3:0 | ||||
| 3. Ronde | 01.08.2021 | NK Osijek | - | Slaven Belupo | 0:0 | ||||
| 4. Ronde | 08.08.2021 | Hrvatski Dragovoljac | - | NK Osijek | 1:2 | ||||
| 9. Ronde | 19.09.2021 | NK Osijek | - | HNK Gorica | 3:2 | ||||
| 11. Ronde | 03.10.2021 | NK Osijek | - | Hajduk Split | 1:1 | ||||
| 18. Ronde | 04.12.2021 | HNK Gorica | - | NK Osijek | 1:1 | ||||
| 14. Ronde | 08.12.2021 | HNK Rijeka | - | NK Osijek | 0:0 | ||||
| 20. Ronde | 19.12.2021 | Hajduk Split | - | NK Osijek | 0:0 |  |
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| 23. Ronde | 13.02.2022 | NK Osijek | - | HNK Rijeka | 1:0 | ||||
| 24. Ronde | 19.02.2022 | NK Istra 1961 | - | NK Osijek | 2:3 | |
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| 27. Ronde | 13.03.2022 | NK Osijek | - | HNK Gorica | 0:0 | ||||
| 28. Ronde | 20.03.2022 | HNK Šibenik | - | NK Osijek | 0:3 | ||||
| 29. Ronde | 03.04.2022 | NK Osijek | - | Hajduk Split | 0:0 | |
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| 30. Ronde | 10.04.2022 | Slaven Belupo | - | NK Osijek | 0:1 | ||||
| 31. Ronde | 16.04.2022 | NK Osijek | - | Hrvatski Dragovoljac | 2:1 | ||||
| 32. Ronde | 23.04.2022 | HNK Rijeka | - | NK Osijek | 3:1 | ||||
| 33. Ronde | 01.05.2022 | NK Osijek | - | NK Istra 1961 | 2:2 | ||||
| 34. Ronde | 08.05.2022 | Dinamo Zagreb | - | NK Osijek | 3:0 |  |
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| 36. Ronde | 21.05.2022 | HNK Gorica | - | NK Osijek | 1:1 |
Oekraïne