| 1. Ronde | 08.08.2021 | FC Metz | - | Lille OSC | 3:3 | ||||
| 2. Ronde | 14.08.2021 | Lille OSC | - | OGC Nice | 0:4 |  |
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| 3. Ronde | 21.08.2021 | AS Saint-Étienne | - | Lille OSC | 1:1 | ||||
| 4. Ronde | 29.08.2021 | Lille OSC | - | Montpellier HSC | 2:1 |  |
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| 5. Ronde | 10.09.2021 | FC Lorient | - | Lille OSC | 2:1 | ||||
| 6. Ronde | 18.09.2021 | RC Lens | - | Lille OSC | 1:0 | ||||
| 7. Ronde | 22.09.2021 | Lille OSC | - | Stade de Reims | 2:1 | |
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| 8. Ronde | 25.09.2021 | RC Strasbourg | - | Lille OSC | 1:2 | ||||
| 9. Ronde | 03.10.2021 | Lille OSC | - | Olympique Marseille | 2:0 | ||||
| 10. Ronde | 16.10.2021 | Clermont Foot 63 | - | Lille OSC | 1:0 | ||||
| 12. Ronde | 29.10.2021 | Paris Saint-Germain | - | Lille OSC | 2:1 | ||||
| 13. Ronde | 06.11.2021 | Lille OSC | - | Angers SCO | 1:1 | ||||
| 14. Ronde | 19.11.2021 | AS Monaco | - | Lille OSC | 2:2 | |
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| 15. Ronde | 27.11.2021 | Lille OSC | - | FC Nantes | 1:1 | ||||
| 17. Ronde | 04.12.2021 | Lille OSC | - | ESTAC Troyes | 2:1 |
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