 |
 |
|
|
| U | Butrinti Sarandë | - | KF Laçi | 1:1 | ||
| R | KF Laçi | - | Butrinti Sarandë | 4:0 | ||
| U: 22.09.2021 13:30 | R: 13.10.2021 13:30 | Winnaars: KF Laçi | ||||
| U | KS Besa | - | KS Pogradeci | 1:0 | ||
| R | KS Pogradeci | - | KS Besa | 2:0 | ||
| U: 22.09.2021 14:00 | R: 13.10.2021 13:30 | Winnaars: KS Pogradeci | ||||
| U | KF Tërbuni Pukë | - | FK Partizani | 0:3 | ||
| R | FK Partizani | - | KF Tërbuni Pukë | 3:0 | ||
| U: 22.09.2021 16:00 | R: 13.10.2021 13:30 | Winnaars: FK Partizani | ||||
| U | KS Shkumbini | - | KF Tiranë | 0:3 | ||
| R | KF Tiranë | - | KS Shkumbini | 6:0 | ||
| U: 22.09.2021 16:00 | R: 13.10.2021 13:30 | Winnaars: KF Tiranë | ||||
| U | KF Veleçiku Koplik | - | KF Skënderbeu | 0:3 | ||
| R | KF Skënderbeu | - | KF Veleçiku Koplik | 4:0 | ||
| U: 22.09.2021 16:00 | R: 13.10.2021 13:30 | Winnaars: KF Skënderbeu | ||||
| U | KF Oriku | - | KF Bylis Ballsh | 1:2 | ||
| R | KF Bylis Ballsh | - | KF Oriku | 4:0 | ||
| U: 22.09.2021 16:00 | R: 14.10.2021 13:30 | Winnaars: KF Bylis Ballsh | ||||
| U | Erzeni Shijak | - | Dinamo Tiranë | 1:0 | ||
| R | Dinamo Tiranë | - | Erzeni Shijak | 2:0 | ||
| U: 22.09.2021 16:00 | R: 14.10.2021 13:30 | Winnaars: Dinamo Tiranë | ||||
| U | KS Besëlidhja Lezhë | - | KS Burreli | 0:0 | ||
| R | KS Burreli | - | KS Besëlidhja Lezhë | 2:4 | ||
| U: 22.09.2021 16:00 | R: 14.10.2021 13:30 | Winnaars: KS Besëlidhja Lezhë | ||||
| U | FK Vora | - | KS Korabi Peshkopi | 2:1 | ||
| R | KS Korabi Peshkopi | - | FK Vora | 4:1 | ||
| U: 22.09.2021 16:00 | R: 13.10.2021 13:30 | Winnaars: KS Korabi Peshkopi | ||||
| U | KF Maliqi | - | FK Kukësi | 0:0 | ||
| R | FK Kukësi | - | KF Maliqi | 4:0 | ||
| U: 22.09.2021 16:00 | R: 13.10.2021 13:30 | Winnaars: FK Kukësi | ||||
| U | KF Elbasani | - | KS Kastrioti | 0:2 | ||
| R | KS Kastrioti | - | KF Elbasani | 2:0 | ||
| U: 22.09.2021 16:00 | R: 13.10.2021 13:30 | Winnaars: KS Kastrioti | ||||
| U | Flamurtari Vlorë | - | KF Apolonia Fier | 1:1 | ||
| R | KF Apolonia Fier | - | Flamurtari Vlorë | 5:6 (1:0, 1:1, 1:1) d.p. | ||
| U: 22.09.2021 16:00 | R: 13.10.2021 13:30 | Winnaars: Flamurtari Vlorë | ||||
| U | Turbina Cërrik | - | Egnatia Rrogozhine | 1:1 | ||
| R | Egnatia Rrogozhine | - | Turbina Cërrik | 1:0 | ||
| U: 22.09.2021 16:00 | R: 13.10.2021 13:30 | Winnaars: Egnatia Rrogozhine | ||||
| U | KF Lushnja | - | FK Tomori Berat | 0:3 | ||
| R | FK Tomori Berat | - | KF Lushnja | 0:0 | ||
| U: 22.09.2021 16:00 | R: 14.10.2021 13:30 | Winnaars: FK Tomori Berat | ||||
| U | Luzi United | - | KF Teuta Durrës | 1:4 | ||
| R | KF Teuta Durrës | - | Luzi United | 2:2 | ||
| U: 22.09.2021 16:00 | R: 13.10.2021 13:30 | Winnaars: KF Teuta Durrës | ||||
| U | Labëria FC | - | FK Vllaznia | 2:1 | ||
| R | FK Vllaznia | - | Labëria FC | 4:0 | ||
| U: 22.09.2021 16:00 | R: 13.10.2021 13:30 | Winnaars: FK Vllaznia | ||||
