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| U | Bolívar | - | The Strongest | 1:0 (0:0) | ||
| R | The Strongest | - | Bolívar | 4:0 (1:0) | ||
| U: 04.12.2011 01:00 | R: 08.12.2011 01:00 | Winnaars: The Strongest | ||||
| U | San José | - | Club Aurora | 1:0 (0:0) | ||
| R | Club Aurora | - | San José | 0:2 (0:1) | ||
| U: 04.12.2011 20:00 | R: 08.12.2011 01:00 | Winnaars: San José | ||||
| U | Nacional Potosí | - | Universitario de Sucre | 2:3 (1:1) | ||
| R | Universitario de Sucre | - | Nacional Potosí | 1:0 (0:0) | ||
| U: 04.12.2011 22:00 | R: 08.12.2011 01:00 | Winnaars: Universitario de Sucre | ||||
| U | CD Guabirá | - | Oriente Petrolero | 0:0 (0:0) | ||
| R | Oriente Petrolero | - | CD Guabirá | 4:1 (2:1) | ||
| U: 05.12.2011 01:00 | R: 08.12.2011 01:30 | Winnaars: Oriente Petrolero | ||||
