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| U | Santos de Guápiles | - | Barrio México | 3:0 | ||
| R | Barrio México | - | Santos de Guápiles | 0:3 | ||
| U: 13.11.2010 | R: 20.11.2010 | Winnaars: Santos de Guápiles | ||||
| U | Brujas de Escazú | - | CS Cartaginés | 2:3 (2:1) | ||
| R | CS Cartaginés | - | Brujas de Escazú | 1:1 (1:1) | ||
| U: 13.11.2010 22:00 | R: 21.11.2010 18:00 | Winnaars: CS Cartaginés | ||||
| U | AD San Carlos | - | CS Herediano | 2:0 (1:0) | ||
| R | CS Herediano | - | AD San Carlos | 4:0 (3:0) | ||
| U: 14.11.2010 02:00 | R: 21.11.2010 03:00 | Winnaars: CS Herediano | ||||
| U | Municipal Pérez Zeledón | - | LD Alajuelense | 2:2 (0:2) | ||
| R | LD Alajuelense | - | Municipal Pérez Zeledón | 4:1 (1:1) | ||
| U: 14.11.2010 04:00 | R: 21.11.2010 18:00 | Winnaars: LD Alajuelense | ||||
