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| U | Deportivo Saprissa | - | CS Herediano | 3:0 (2:0) | ||
| R | CS Herediano | - | Deportivo Saprissa | 1:0 (1:0) | ||
| U: 02.12.2021 03:00 | R: 06.12.2021 02:30 | Winnaars: Deportivo Saprissa | ||||
| U | Santos de Guápiles | - | LD Alajuelense | 3:2 (2:1) | ||
| R | LD Alajuelense | - | Santos de Guápiles | 1:0 (1:0) | ||
| U: 03.12.2021 02:00 | R: 05.12.2021 23:00 | Winnaars: LD Alajuelense | ||||
