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| 22.01.2022 | 17:00 | Andrézieux-Bouthéon FC | - | Vendée Les Herbiers | 1:2 (0:2) | |
| 17:00 | Moulins Yzeure Foot | - | Bergerac Périgord FC | 0:0 (0:0) | ||
| 18:00 | Angoulême CFC | - | Stade Montois | 4:1 (1:1) | ||
| 18:00 | Canet Roussillon | - | Bourges Foot 18 | 0:2 (0:0) | ||
| 18:00 | FC Nantes B | - | Le Puy Foot 43 | 0:0 (0:0) | ||
| 18:00 | US Colomiers | - | Angers SCO B | 0:0 (0:0) | ||
| 18:00 | FC Chamalières | - | Montpellier HSC B | 1:2 (1:1) | ||
| 23.02.2022 | 19:00 | Trélissac FC | - | AS Béziers | 0:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bergerac Périgord FC | 16 | 9 | 5 | 2 | 21:9 | 12 | 32 |
| 2 |
|
Angoulême CFC | 16 | 8 | 5 | 3 | 24:15 | 9 | 29 |
| 3 |
|
Moulins Yzeure Foot | 16 | 7 | 7 | 2 | 15:10 | 5 | 28 |
| 4 |
|
Bourges Foot 18 | 16 | 8 | 3 | 5 | 24:14 | 10 | 27 |
| 5 |
|
Le Puy Foot 43 | 16 | 7 | 5 | 4 | 19:11 | 8 | 26 |
| 6 |
|
Andrézieux-Bouthéon FC | 16 | 8 | 2 | 6 | 21:16 | 5 | 26 |
| 7 |
|
FC Nantes B | 16 | 6 | 7 | 3 | 22:15 | 7 | 25 |
| 8 |
|
AS Béziers | 16 | 7 | 4 | 5 | 20:15 | 5 | 25 |
| 9 |
|
Vendée Les Herbiers | 16 | 5 | 6 | 5 | 19:21 | -2 | 21 |
| 10 |
|
Trélissac FC | 16 | 5 | 4 | 7 | 11:14 | -3 | 19 |
| 11 |
|
Angers SCO B | 16 | 4 | 6 | 6 | 18:18 | 0 | 18 |
| 12 |
|
FC Chamalières | 16 | 5 | 3 | 8 | 21:26 | -5 | 18 |
| 13 |
|
US Colomiers | 16 | 3 | 6 | 7 | 12:20 | -8 | 15 |
| 14 |
|
Canet Roussillon | 16 | 7 | 4 | 5 | 15:19 | -4 | 14 |
| 15 |
|
Montpellier HSC B | 16 | 4 | 2 | 10 | 17:26 | -9 | 14 |
| 16 |
|
Stade Montois | 16 | 0 | 1 | 15 | 12:42 | -30 | 1 |
| Promotie | |
| Degradatie |
