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| 11.03.2022 | 19:30 | Andrézieux-Bouthéon FC | - | FC Nantes B | 3:1 (2:1) | |
| 12.03.2022 | 18:00 | Bourges Foot 18 | - | Stade Montois | 2:0 (1:0) | |
| 18:00 | Bergerac Périgord FC | - | US Colomiers | 1:0 (1:0) | ||
| 18:00 | Montpellier HSC B | - | Angoulême CFC | 0:0 (0:0) | ||
| 18:00 | Le Puy Foot 43 | - | AS Béziers | 2:0 (2:0) | ||
| 18:00 | Angers SCO B | - | Moulins Yzeure Foot | 1:1 (0:1) | ||
| 18:00 | Vendée Les Herbiers | - | Trélissac FC | 2:0 (1:0) | ||
| 20:00 | FC Chamalières | - | Canet Roussillon | 0:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bergerac Périgord FC | 21 | 11 | 8 | 2 | 24:10 | 14 | 41 |
| 2 |
|
Angoulême CFC | 21 | 11 | 7 | 3 | 27:15 | 12 | 40 |
| 3 |
|
Bourges Foot 18 | 21 | 11 | 4 | 6 | 31:18 | 13 | 37 |
| 4 |
|
Le Puy Foot 43 | 21 | 10 | 6 | 5 | 27:14 | 13 | 36 |
| 5 |
|
Andrézieux-Bouthéon FC | 21 | 10 | 5 | 6 | 29:20 | 9 | 35 |
| 6 |
|
Moulins Yzeure Foot | 21 | 8 | 9 | 4 | 22:17 | 5 | 33 |
| 7 |
|
FC Nantes B | 21 | 7 | 8 | 6 | 26:23 | 3 | 29 |
| 8 |
|
AS Béziers | 21 | 8 | 5 | 8 | 26:24 | 2 | 29 |
| 9 |
|
Vendée Les Herbiers | 21 | 7 | 6 | 8 | 25:27 | -2 | 27 |
| 10 |
|
Angers SCO B | 21 | 5 | 9 | 7 | 21:22 | -1 | 24 |
| 11 |
|
Trélissac FC | 21 | 6 | 6 | 9 | 17:20 | -3 | 24 |
| 12 |
|
FC Chamalières | 21 | 6 | 5 | 10 | 24:29 | -5 | 23 |
| 13 |
|
Canet Roussillon | 21 | 9 | 5 | 7 | 18:23 | -5 | 21 |
| 14 |
|
US Colomiers | 21 | 4 | 8 | 9 | 19:28 | -9 | 20 |
| 15 |
|
Montpellier HSC B | 21 | 5 | 5 | 11 | 19:29 | -10 | 20 |
| 16 |
|
Stade Montois | 21 | 1 | 2 | 18 | 14:50 | -36 | 5 |
| Promotie | |
| Degradatie |
