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| 19.03.2022 | 18:00 | Angoulême CFC | - | FC Chamalières | 2:0 (1:0) | |
| 18:00 | AS Béziers | - | Angers SCO B | 1:1 (0:0) | ||
| 18:00 | Bourges Foot 18 | - | Bergerac Périgord FC | 1:2 (1:0) | ||
| 18:00 | Canet Roussillon | - | Andrézieux-Bouthéon FC | 0:2 (0:0) | ||
| 18:00 | FC Nantes B | - | US Colomiers | 2:1 (1:0) | ||
| 18:00 | Trélissac FC | - | Montpellier HSC B | 3:0 (3:0) | ||
| 18:30 | Moulins Yzeure Foot | - | Vendée Les Herbiers | 0:1 (0:1) | ||
| 18:30 | Stade Montois | - | Le Puy Foot 43 | 0:1 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bergerac Périgord FC | 22 | 12 | 8 | 2 | 26:11 | 15 | 44 |
| 2 |
|
Angoulême CFC | 22 | 12 | 7 | 3 | 29:15 | 14 | 43 |
| 3 |
|
Le Puy Foot 43 | 22 | 11 | 6 | 5 | 28:14 | 14 | 39 |
| 4 |
|
Andrézieux-Bouthéon FC | 22 | 11 | 5 | 6 | 31:20 | 11 | 38 |
| 5 |
|
Bourges Foot 18 | 22 | 11 | 4 | 7 | 32:20 | 12 | 37 |
| 6 |
|
Moulins Yzeure Foot | 22 | 8 | 9 | 5 | 22:18 | 4 | 33 |
| 7 |
|
FC Nantes B | 22 | 8 | 8 | 6 | 28:24 | 4 | 32 |
| 8 |
|
AS Béziers | 22 | 8 | 6 | 8 | 27:25 | 2 | 30 |
| 9 |
|
Vendée Les Herbiers | 22 | 8 | 6 | 8 | 26:27 | -1 | 30 |
| 10 |
|
Trélissac FC | 22 | 7 | 6 | 9 | 20:20 | 0 | 27 |
| 11 |
|
Angers SCO B | 22 | 5 | 10 | 7 | 22:23 | -1 | 25 |
| 12 |
|
FC Chamalières | 22 | 6 | 5 | 11 | 24:31 | -7 | 23 |
| 13 |
|
Canet Roussillon | 22 | 9 | 5 | 8 | 18:25 | -7 | 21 |
| 14 |
|
US Colomiers | 22 | 4 | 8 | 10 | 20:30 | -10 | 20 |
| 15 |
|
Montpellier HSC B | 22 | 5 | 5 | 12 | 19:32 | -13 | 20 |
| 16 |
|
Stade Montois | 22 | 1 | 2 | 19 | 14:51 | -37 | 5 |
| Promotie | |
| Degradatie |
