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| U | Metalurg Skopje | - | FK Turnovo | 3:3 | ||
| R | FK Turnovo | - | Metalurg Skopje | 0:1 | ||
| U: 09.09.2012 15:30 | R: 26.09.2012 15:00 | Winnaars: Metalurg Skopje | ||||
| U | Lokomotiva Skopje | - | FK Teteks | 0:2 | ||
| R | FK Teteks | - | Lokomotiva Skopje | 7:0 (2:0) | ||
| U: 09.09.2012 15:30 | R: 26.09.2012 15:00 | Winnaars: FK Teteks | ||||
| U | KF Shkëndija 79 | - | FK Bregalnica Štip | 1:0 | ||
| R | FK Bregalnica Štip | - | KF Shkëndija 79 | 0:1 | ||
| U: 09.09.2012 15:30 | R: 26.09.2012 15:00 | Winnaars: KF Shkëndija 79 | ||||
| U | KF Bashkimi | - | Sileks Kratovo | 0:1 | ||
| R | Sileks Kratovo | - | KF Bashkimi | 3:0 | ||
| U: 09.09.2012 15:30 | R: 26.09.2012 15:00 | Winnaars: Sileks Kratovo | ||||
| U | FK Pelister | - | Babi Štip | 5:0 | ||
| R | Babi Štip | - | FK Pelister | 1:1 (1:1) | ||
| U: 09.09.2012 15:30 | R: 27.09.2012 15:00 | Winnaars: FK Pelister | ||||
| U | FK Viktorija | - | FK Drita | 0:0 | ||
| R | FK Drita | - | FK Viktorija | 2:0 | ||
| U: 09.09.2012 15:30 | R: 26.09.2012 15:00 | Winnaars: FK Drita | ||||
| U | 11 Oktomvri | - | FK Renova | 0:5 | ||
| R | FK Renova | - | 11 Oktomvri | 5:0 | ||
| U: 09.09.2012 15:30 | R: 26.09.2012 15:00 | Winnaars: FK Renova | ||||
| U | Vardar Skopje | - | FK Gorno Lisiče | 2:0 (2:0) | ||
| R | FK Gorno Lisiče | - | Vardar Skopje | 1:2 | ||
| U: 19.09.2012 20:00 | R: 26.09.2012 15:00 | Winnaars: Vardar Skopje | ||||
