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| U | Diriangén FC | - | CD Walter Ferretti | 3:2 (0:2) | ||
| R | CD Walter Ferretti | - | Diriangén FC | 1:3 (0:3) | ||
| U: 29.11.2020 02:00 | R: 06.12.2020 23:00 | Winnaars: Diriangén FC | ||||
| U | Chinandega | - | Real Estelí FC | 2:2 (0:1) | ||
| R | Real Estelí FC | - | Chinandega | 1:0 (1:0) | ||
| U: 29.11.2020 22:00 | R: 07.12.2020 02:00 | Winnaars: Real Estelí FC | ||||
