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| U | Once Municipal | - | Alianza | 1:1 (1:0) | ||
| R | Alianza | - | Once Municipal | 2:0 (1:0) | ||
| U: 08.12.2021 22:30 | R: 12.12.2021 22:00 | Winnaars: Alianza | ||||
| U | AD Chalatenango | - | Platense Zacatecoluca | 1:1 (1:0) | ||
| R | Platense Zacatecoluca | - | AD Chalatenango | 1:0 (0:0) | ||
| U: 10.12.2021 02:00 | R: 12.12.2021 22:00 | Winnaars: Platense Zacatecoluca | ||||
