| 3. Ronde | 21.08.2021 | Leixões SC [A-jun] | - | CD Feirense [A-jun] | 2:1 |  |
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| 4. Ronde | 28.08.2021 | Vitória Guimarães [A-jun] | - | Leixões SC [A-jun] | 2:1 |  |
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| 5. Ronde | 11.09.2021 | Leixões SC [A-jun] | - | FC Famalicão [A-jun] | 1:3 | ||||
| 7. Ronde | 25.09.2021 | Leixões SC [A-jun] | - | Rio Ave FC [A-jun] | 0:2 | ||||
| 8. Ronde | 02.10.2021 | Paços de Ferreira [A-jun] | - | Leixões SC [A-jun] | 3:2 |
Guinea-Bissau