| 3. Ronde | 07.08.2021 | Cruz Azul [U16] | - | Club Tijuana [U16] | 3:0 |  |
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| 4. Ronde | 14.08.2021 | Club Tijuana [U16] | - | FC Juárez [U16] | 1:1 | ||||
| 5. Ronde | 21.08.2021 | Puebla FC [U16] | - | Club Tijuana [U16] | 3:0 | ||||
| 6. Ronde | 28.08.2021 | CF Pachuca [U16] | - | Club Tijuana [U16] | 1:0 | ||||
| 7. Ronde | 04.09.2021 | Club Tijuana [U16] | - | CF América [U16] | 2:1 | ||||
| 16. Ronde | 06.11.2021 | FC Juárez [U16] | - | Club Tijuana [U16] | 1:3 | ||||
| 17. Ronde | 13.11.2021 | Pumas UNAM [U16] | - | Club Tijuana [U16] | 0:0 | ||||
| 18. Ronde | 20.11.2021 | Club Tijuana [U16] | - | Cruz Azul [U16] | 0:0 |
Verenigde Staten