| 8. Ronde | 13.09.2021 | Pumas UNAM | - | Deportivo Guadalajara | 0:0 | ||||
| 10. Ronde | 26.09.2021 | UANL Tigres | - | Pumas UNAM | 0:0 | ||||
| 13. Ronde | 17.10.2021 | Pumas UNAM | - | FC Juárez | 1:0 | ||||
| 15. Ronde | 24.10.2021 | Pumas UNAM | - | Club Tijuana | 3:1 | ||||
| 16. Ronde | 31.10.2021 | CF Pachuca | - | Pumas UNAM | 1:1 | ||||
| 17. Ronde | 08.11.2021 | Pumas UNAM | - | Cruz Azul | 4:3 |
Mexico