| 1. Ronde | 25.07.2021 | Spartak Trnava | - | FK Pohronie | 2:0 | ||||
| 2. Ronde | 31.07.2021 | FK Pohronie | - | MFK Zemplín Michalovce | 2:0 | ||||
| 3. Ronde | 08.08.2021 | MŠK Žilina | - | FK Pohronie | 3:1 | ||||
| 4. Ronde | 14.08.2021 | FK Pohronie | - | ŠKF Sereď | 1:1 | ||||
| 5. Ronde | 20.08.2021 | Zlaté Moravce | - | FK Pohronie | 1:0 | ||||
| 6. Ronde | 27.08.2021 | FK Pohronie | - | FC DAC 1904 | 0:3 |  |
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| 8. Ronde | 18.09.2021 | Tatran Liptovský Mikuláš | - | FK Pohronie | 5:1 | ||||
| 9. Ronde | 24.09.2021 | FK Pohronie | - | AS Trenčín | 2:2 | ||||
| 13. Ronde | 30.10.2021 | MFK Zemplín Michalovce | - | FK Pohronie | 0:2 | ||||
| 17. Ronde | 04.12.2021 | FC DAC 1904 | - | FK Pohronie | 2:0 |
Polen