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| 03.12.2021 | 17:00 | Zlaté Moravce | - | Slovan Bratislava | 1:2 (0:0) | |
| 04.12.2021 | 15:00 | FK Senica | - | Tatran Liptovský Mikuláš | 1:0 (0:0) | |
| 15:00 | MFK Zemplín Michalovce | - | MFK Ružomberok | 0:3 (0:2) | ||
| 15:00 | FC DAC 1904 | - | FK Pohronie | 2:0 (2:0) | ||
| 15:00 | ŠKF Sereď | - | AS Trenčín | 4:2 (2:0) | ||
| 05.12.2021 | 17:00 | MŠK Žilina | - | Spartak Trnava | 0:1 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Slovan Bratislava | 17 | 14 | 2 | 1 | 42:12 | 30 | 44 |
| 2 |
|
Spartak Trnava | 17 | 11 | 3 | 3 | 25:11 | 14 | 36 |
| 3 |
|
MFK Ružomberok | 17 | 9 | 6 | 2 | 30:12 | 18 | 33 |
| 4 |
|
FC DAC 1904 | 17 | 9 | 3 | 5 | 24:19 | 5 | 30 |
| 5 |
|
MŠK Žilina | 17 | 6 | 5 | 6 | 26:22 | 4 | 23 |
| 6 |
|
ŠKF Sereď | 17 | 6 | 4 | 7 | 22:24 | -2 | 22 |
| 7 |
|
AS Trenčín | 17 | 5 | 5 | 7 | 26:27 | -1 | 20 |
| 8 |
|
MFK Zemplín Michalovce | 17 | 6 | 2 | 9 | 18:25 | -7 | 20 |
| 9 |
|
FK Senica | 17 | 4 | 6 | 7 | 17:25 | -8 | 18 |
| 10 |
|
Zlaté Moravce | 17 | 3 | 5 | 9 | 18:32 | -14 | 14 |
| 11 |
|
Tatran Liptovský Mikuláš | 17 | 4 | 2 | 11 | 19:36 | -17 | 14 |
| 12 |
|
FK Pohronie | 17 | 2 | 3 | 12 | 14:36 | -22 | 9 |
| Play-offs | |
| Promotie en degradatie |
