| 1. Ronde | 26.07.2021 | Cruz Azul [U18] | - | Mazatlán FC [U18] | 1:1 | ||||
| 2. Ronde | 01.08.2021 | Santos Laguna [U18] | - | Cruz Azul [U18] | 1:2 |  |
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| 3. Ronde | 06.08.2021 | Club Necaxa [U18] | - | Cruz Azul [U18] | 5:0 | ||||
| 5. Ronde | 18.08.2021 | Cruz Azul [U18] | - | CF Monterrey [U18] | 1:1 | ||||
| 6. Ronde | 21.08.2021 | Atlético San Luis [U18] | - | Cruz Azul [U18] | 2:3 | |
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| 7. Ronde | 29.08.2021 | Cruz Azul [U18] | - | CF Pachuca [U18] | 1:0 | |
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| 8. Ronde | 10.09.2021 | FC Juárez [U18] | - | Cruz Azul [U18] | 5:0 | ||||
| 9. Ronde | 19.09.2021 | Cruz Azul [U18] | - | Gallos Blancos [U18] | 1:1 | |
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| 10. Ronde | 24.09.2021 | Puebla FC [U18] | - | Cruz Azul [U18] | 2:1 |  |
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| 13. Ronde | 16.10.2021 | Cruz Azul [U18] | - | UANL Tigres [U18] | 0:1 | ||||
| 14. Ronde | 19.10.2021 | Atlas Guadalajara [U18] | - | Cruz Azul [U18] | 5:2 | ||||
| 15. Ronde | 23.10.2021 | Deportivo Guadalajara [U18] | - | Cruz Azul [U18] | 2:1 |  |
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| 16. Ronde | 31.10.2021 | Cruz Azul [U18] | - | CF América [U18] | 0:0 | |
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| 11. Ronde | 03.11.2021 | Cruz Azul [U18] | - | Club León [U18] | 2:3 | ||||
| 17. Ronde | 07.11.2021 | Pumas UNAM [U18] | - | Cruz Azul [U18] | 2:2 |
Mexico