| 3. Ronde | 06.08.2021 | Club Necaxa [U20] | - | Cruz Azul [U20] | 1:0 | ||||
| 5. Ronde | 18.08.2021 | Cruz Azul [U20] | - | CF Monterrey [U20] | 2:1 | ||||
| 6. Ronde | 21.08.2021 | Atlético San Luis [U20] | - | Cruz Azul [U20] | 0:0 | ||||
| 7. Ronde | 29.08.2021 | Cruz Azul [U20] | - | CF Pachuca [U20] | 0:0 | ||||
| 10. Ronde | 24.09.2021 | Puebla FC [U20] | - | Cruz Azul [U20] | 0:0 | ||||
| 12. Ronde | 04.10.2021 | Club Tijuana [U20] | - | Cruz Azul [U20] | 0:1 |  |
Mexico