| 1. Ronde | 16.01.2021 | Orsomarso SC | - | Barranquilla FC | 2:2 | ||||
| 2. Ronde | 23.01.2021 | Barranquilla FC | - | Boca Juniors de Cali | 0:1 | ||||
| 3. Ronde | 01.02.2021 | Real Cartagena | - | Barranquilla FC | 1:0 | ||||
| 4. Ronde | 06.02.2021 | Barranquilla FC | - | Real Santander | 1:0 | ||||
| 5. Ronde | 11.02.2021 | Bogotá FC | - | Barranquilla FC | 1:0 |  |
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| 6. Ronde | 15.02.2021 | Barranquilla FC | - | Fortaleza FC | 1:2 | ||||
| 7. Ronde | 22.02.2021 | Leones FC | - | Barranquilla FC | 2:1 | ||||
| 8. Ronde | 27.02.2021 | Barranquilla FC | - | Atlético Huila | 0:0 | ||||
| 9. Ronde | 04.03.2021 | Cortuluá | - | Barranquilla FC | 1:1 | ||||
| 10. Ronde | 07.03.2021 | Barranquilla FC | - | Atlético FC | 0:1 | ||||
| 12. Ronde | 21.03.2021 | Valledupar FC | - | Barranquilla FC | 2:0 | ||||
| 15. Ronde | 09.04.2021 | Barranquilla FC | - | Deportes Quindío | 0:0 |
Colombia