| 7. Ronde | 21.02.2021 | Atlas Guadalajara | - | CF América | 3:0 Toeg. | ||||
| 8. Ronde | 28.02.2021 | CF América | - | CF Pachuca | 2:0 | ||||
| 9. Ronde | 04.03.2021 | Club Tijuana | - | CF América | 0:2 | ||||
| 10. Ronde | 07.03.2021 | CF América | - | Club León | 2:1 | ||||
| 11. Ronde | 15.03.2021 | Deportivo Guadalajara | - | CF América | 0:3 | ||||
| 12. Ronde | 20.03.2021 | Mazatlán FC | - | CF América | 0:1 | ||||
| 13. Ronde | 04.04.2021 | CF América | - | Club Necaxa | 2:1 | ||||
| 14. Ronde | 11.04.2021 | UANL Tigres | - | CF América | 1:3 | ||||
| 15. Ronde | 18.04.2021 | CF América | - | Cruz Azul | 1:1 | ||||
| 16. Ronde | 26.04.2021 | Deportivo Toluca | - | CF América | 3:1 |
Spanje
Mexico