| 1. Ronde | 23.07.2021 | Gallos Blancos | - | CF América | 0:0 | ||||
| 2. Ronde | 01.08.2021 | CF América | - | Club Necaxa | 2:1 |  |
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| 3. Ronde | 08.08.2021 | CF América | - | Puebla FC | 2:0 | ||||
| 4. Ronde | 16.08.2021 | Atlas Guadalajara | - | CF América | 0:1 | ||||
| 5. Ronde | 19.08.2021 | FC Juárez | - | CF América | 1:2 | |
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| 6. Ronde | 23.08.2021 | CF América | - | Club Tijuana | 2:0 | ||||
| 7. Ronde | 29.08.2021 | Club León | - | CF América | 1:1 |  |
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| 8. Ronde | 12.09.2021 | CF América | - | Mazatlán FC | 2:0 | |
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| 10. Ronde | 26.09.2021 | CF América | - | Deportivo Guadalajara | 0:0 | ||||
| 11. Ronde | 29.09.2021 | CF Pachuca | - | CF América | 1:1 | ||||
| 12. Ronde | 04.10.2021 | CF América | - | Pumas UNAM | 2:0 | ||||
| 13. Ronde | 17.10.2021 | Atlético San Luis | - | CF América | 0:1 | ||||
| 14. Ronde | 20.10.2021 | CF América | - | Santos Laguna | 2:1 | |
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| 15. Ronde | 24.10.2021 | CF América | - | UANL Tigres | 1:0 | ||||
| 16. Ronde | 01.11.2021 | Cruz Azul | - | CF América | 2:1 | ||||
| 17. Ronde | 07.11.2021 | CF América | - | CF Monterrey | 0:0 |
Spanje
Mexico