| 1. Ronde | 09.01.2022 | Pumas UNAM [U20] | - | Deportivo Toluca [U20] | 1:1 | ||||
| 2. Ronde | 14.01.2022 | Gallos Blancos [U20] | - | Pumas UNAM [U20] | 0:1 |  |
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| 14. Ronde | 27.01.2022 | Pumas UNAM [U20] | - | CF Monterrey [U20] | 4:0 | |
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| 10. Ronde | 12.03.2022 | Cruz Azul [U20] | - | Pumas UNAM [U20] | 1:0 Toeg. | ||||
| 11. Ronde | 19.03.2022 | Pumas UNAM [U20] | - | Club Necaxa [U20] | 1:2 | |
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| 9. Ronde | 27.03.2022 | Pumas UNAM [U20] | - | Mazatlán FC [U20] | 3:0 | ||||
| 13. Ronde | 08.04.2022 | Puebla FC [U20] | - | Pumas UNAM [U20] | 2:2 | |
Mexico