| 4. Ronde | 26.09.2021 | PAOK Saloniki | - | AEK Athene | 2:0 | ||||
| 5. Ronde | 03.10.2021 | Panetolikos | - | AEK Athene | 1:3 |  |
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| 6. Ronde | 17.10.2021 | AEK Athene | - | Atromitos | 3:0 | ||||
| 7. Ronde | 24.10.2021 | Volos NFC | - | AEK Athene | 1:3 | ||||
| 8. Ronde | 31.10.2021 | AEK Athene | - | Aris Saloniki | 2:1 | |
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| 9. Ronde | 06.11.2021 | Apollon Smyrnis | - | AEK Athene | 2:2 | ||||
| 10. Ronde | 21.11.2021 | AEK Athene | - | Olympiakos | 2:3 | ||||
| 11. Ronde | 27.11.2021 | PAS Giannina | - | AEK Athene | 1:2 | ||||
| 12. Ronde | 05.12.2021 | AEK Athene | - | Panathinaikos | 1:0 | |
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| 13. Ronde | 11.12.2021 | Asteras Tripolis | - | AEK Athene | 0:0 | |
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| 15. Ronde | 20.12.2021 | AEK Athene | - | OFI Heraklion | 1:2 | ||||
| 16. Ronde | 05.01.2022 | Lamia | - | AEK Athene | 0:2 | |
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| 18. Ronde | 16.01.2022 | AEK Athene | - | Panetolikos | 1:2 | |
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| 19. Ronde | 23.01.2022 | Atromitos | - | AEK Athene | 0:2 | ||||
| 21. Ronde | 02.02.2022 | Aris Saloniki | - | AEK Athene | 2:1 | |
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| 23. Ronde | 13.02.2022 | Olympiakos | - | AEK Athene | 1:0 | ||||
| 25. Ronde | 27.02.2022 | Panathinaikos | - | AEK Athene | 3:0 | ||||
| 17. Ronde | 02.03.2022 | AEK Athene | - | PAOK Saloniki | 1:1 | ||||
| 26. Ronde | 06.03.2022 | AEK Athene | - | Asteras Tripolis | 2:1 | |
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