| 2. Ronde | 19.02.2022 | Vitória Setúbal [A-jun] | - | UD Vilafranquense [A-jun] | 2:2 | ||||
| 4. Ronde | 05.03.2022 | União Leiria [A-jun] | - | Vitória Setúbal [A-jun] | 2:2 | ||||
| 5. Ronde | 12.03.2022 | Vitória Setúbal [A-jun] | - | SG Sacavenense [A-jun] | 3:1 |  |
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| 6. Ronde | 19.03.2022 | Académica de Coimbra [A-jun] | - | Vitória Setúbal [A-jun] | 1:0 | ||||
| 8. Ronde | 09.04.2022 | Vitória Setúbal [A-jun] | - | CD Nacional [A-jun] | 0:2 |  |
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| 10. Ronde | 23.04.2022 | Amora FC [A-jun] | - | Vitória Setúbal [A-jun] | 1:0 |
Portugal