| 3. Ronde | 08.08.2020 | CF Monterrey [U20] | - | Santos Laguna [U20] | 2:1 |  |
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| 4. Ronde | 13.08.2020 | CF América [U20] | - | Santos Laguna [U20] | 4:0 | ||||
| 5. Ronde | 16.08.2020 | Santos Laguna [U20] | - | Atlas Guadalajara [U20] | 0:2 | ||||
| 6. Ronde | 21.08.2020 | Club Necaxa [U20] | - | Santos Laguna [U20] | 1:2 | ||||
| 7. Ronde | 30.08.2020 | Santos Laguna [U20] | - | Gallos Blancos [U20] | 3:1 | ||||
| 8. Ronde | 04.09.2020 | FC Juárez [U20] | - | Santos Laguna [U20] | 0:1 | ||||
| 9. Ronde | 09.09.2020 | Santos Laguna [U20] | - | Pumas UNAM [U20] | 1:3 | ||||
| 13. Ronde | 02.10.2020 | Puebla FC [U20] | - | Santos Laguna [U20] | 2:1 | ||||
| 1. Ronde | 10.10.2020 | Cruz Azul [U20] | - | Santos Laguna [U20] | 2:1 |
Mexico