| 2. Ronde | 17.01.2021 | Santos Laguna [U20] | - | UANL Tigres [U20] | 2:0 | ||||
| 3. Ronde | 22.01.2021 | Mazatlán FC [U20] | - | Santos Laguna [U20] | 2:2 |  |
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| 4. Ronde | 31.01.2021 | Santos Laguna [U20] | - | CF América [U20] | 0:1 | ||||
| 5. Ronde | 06.02.2021 | Atlas Guadalajara [U20] | - | Santos Laguna [U20] | 0:0 | ||||
| 7. Ronde | 18.02.2021 | Atlético San Luis [U20] | - | Santos Laguna [U20] | 0:4 |  |
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| 8. Ronde | 28.02.2021 | Santos Laguna [U20] | - | FC Juárez [U20] | 3:0 | |
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| 9. Ronde | 04.03.2021 | Pumas UNAM [U20] | - | Santos Laguna [U20] | 0:0 | ||||
| 10. Ronde | 07.03.2021 | Santos Laguna [U20] | - | Club Necaxa [U20] | 1:1 | ||||
| 11. Ronde | 14.03.2021 | Club Tijuana [U20] | - | Santos Laguna [U20] | 3:1 | ||||
| 12. Ronde | 21.03.2021 | Santos Laguna [U20] | - | Club León [U20] | 3:0 | |
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| 1. Ronde | 26.03.2021 | Santos Laguna [U20] | - | Cruz Azul [U20] | 3:1 |
Mexico