| 1. Ronde | 07.08.2021 | SC Cham | - | FC Sion II | 2:1 | ||||
| 3. Ronde | 21.08.2021 | FC Bavois | - | FC Sion II | 3:1 | ||||
| 4. Ronde | 28.08.2021 | FC Sion II | - | FC Stade Nyonnais | 1:1 | ||||
| 6. Ronde | 11.09.2021 | FC Sion II | - | BSC Young Boys II | 2:0 | ||||
| 8. Ronde | 25.09.2021 | FC Sion II | - | FC Biel/Bienne | 1:2 | ||||
| 9. Ronde | 02.10.2021 | FC Basel 1893 II | - | FC Sion II | 6:2 | ||||
| 10. Ronde | 10.10.2021 | FC Rapperswil-Jona | - | FC Sion II | 2:0 |  |
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| 14. Ronde | 06.11.2021 | SC Brühl | - | FC Sion II | 0:1 | ||||
| 15. Ronde | 13.11.2021 | FC Sion II | - | SC YF/Juventus Zürich | 1:3 | |
Zwitserland