| 4. Ronde | 14.08.2021 | Pumas UNAM [U20] | - | Gallos Blancos [U20] | 1:4 |  |
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| 6. Ronde | 22.08.2021 | Pumas UNAM [U20] | - | Puebla FC [U20] | 1:3 | ||||
| 7. Ronde | 29.08.2021 | Deportivo Toluca [U20] | - | Pumas UNAM [U20] | 2:2 | ||||
| 14. Ronde | 20.10.2021 | Club León [U20] | - | Pumas UNAM [U20] | 0:2 | ||||
| 15. Ronde | 24.10.2021 | Pumas UNAM [U20] | - | Club Tijuana [U20] | 4:0 |  |
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| 11. Ronde | 04.11.2021 | Pumas UNAM [U20] | - | Santos Laguna [U20] | 2:1 | ||||
| 17. Ronde | 07.11.2021 | Pumas UNAM [U20] | - | Cruz Azul [U20] | 1:2 |
Mexico