| 1. Ronde | 18.09.2021 | CF Pachuca [] | - | Deportivo Toluca [] | 5:0 | ||||
| 2. Ronde | 25.09.2021 | Puebla FC [] | - | Deportivo Toluca [] | 2:1 | ||||
| 3. Ronde | 02.10.2021 | Deportivo Toluca [] | - | Club Tijuana [] | 3:0 |  |
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| 4. Ronde | 09.10.2021 | Gallos Blancos [] | - | Deportivo Toluca [] | 0:0 | ||||
| 5. Ronde | 16.10.2021 | Deportivo Toluca [] | - | Cruz Azul [] | 3:0 | |
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| 6. Ronde | 23.10.2021 | FC Juárez [] | - | Deportivo Toluca [] | 3:2 | ||||
| 8. Ronde | 06.11.2021 | Deportivo Toluca [] | - | Pumas UNAM [] | 3:1 |
Mexico