| 3. Ronde | 19.07.2022 | CF Pachuca | - | Mazatlán FC | 1:1 | ||||
| 4. Ronde | 23.07.2022 | Mazatlán FC | - | Atlético San Luis | 1:1 | ||||
| 5. Ronde | 28.07.2022 | Pumas UNAM | - | Mazatlán FC | 1:1 | ||||
| 6. Ronde | 31.07.2022 | Club Tijuana | - | Mazatlán FC | 2:0 | ||||
| 7. Ronde | 06.08.2022 | Mazatlán FC | - | Deportivo Guadalajara | 2:1 |  |
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| 8. Ronde | 14.08.2022 | Club León | - | Mazatlán FC | 0:3 | ||||
| 9. Ronde | 17.08.2022 | Mazatlán FC | - | Gallos Blancos | 1:1 | ||||
| 10. Ronde | 21.08.2022 | FC Juárez | - | Mazatlán FC | 1:1 | ||||
| 11. Ronde | 27.08.2022 | Mazatlán FC | - | CF América | 1:3 | ||||
| 12. Ronde | 04.09.2022 | CF Monterrey | - | Mazatlán FC | 0:0 | |
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| 13. Ronde | 08.09.2022 | Mazatlán FC | - | Atlas Guadalajara | 1:0 | |
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| 14. Ronde | 11.09.2022 | Cruz Azul | - | Mazatlán FC | 2:0 | ||||
| 15. Ronde | 17.09.2022 | Mazatlán FC | - | Deportivo Toluca | 1:1 | ||||
| 16. Ronde | 24.09.2022 | Club Necaxa | - | Mazatlán FC | 2:2 | ||||
| 17. Ronde | 03.10.2022 | Santos Laguna | - | Mazatlán FC | 3:0 |
Mexico