| 4. Ronde | 09.03.2022 | Rangers | - | Cobreloa | 1:2 | ||||
| 8. Ronde | 09.04.2022 | Deportes Melipilla | - | Cobreloa | 0:0 | ||||
| 17. Ronde | 28.05.2022 | Santiago Morning | - | Cobreloa | 0:1 | ||||
| 5. Ronde | 02.06.2022 | Cobreloa | - | Santa Cruz | 1:0 | ||||
| 3. Ronde | 06.06.2022 | Cobreloa | - | Deportes Copiapó | 2:0 | ||||
| 20. Ronde | 19.07.2022 | Deportes Copiapó | - | Cobreloa | 2:0 | ||||
| 21. Ronde | 24.07.2022 | Cobreloa | - | Rangers | 1:0 | ||||
| 22. Ronde | 01.08.2022 | Santa Cruz | - | Cobreloa | 1:1 | ||||
| 23. Ronde | 06.08.2022 | Cobreloa | - | CD Magallanes | 1:0 |  |
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| 24. Ronde | 12.08.2022 | Puerto Montt | - | Cobreloa | 1:1 | ||||
| 31. Ronde | 09.10.2022 | Santiago Wanderers | - | Cobreloa | 2:2 | ||||
| 32. Ronde | 15.10.2022 | Cobreloa | - | Deportes Temuco | 1:0 | ||||
| 33. Ronde | 23.10.2022 | Fernández Vial | - | Cobreloa | 2:3 |
Chili