| 1. Ronde | 27.07.2021 | Cruz Azul | - | Mazatlán FC | 0:2 | ||||
| 2. Ronde | 31.07.2021 | Mazatlán FC | - | CF Pachuca | 2:1 |  |
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| 3. Ronde | 07.08.2021 | Mazatlán FC | - | CF Monterrey | 1:1 |  |
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| 5. Ronde | 18.08.2021 | Deportivo Toluca | - | Mazatlán FC | 2:2 | |
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| 6. Ronde | 21.08.2021 | Mazatlán FC | - | UANL Tigres | 0:3 |  |
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| 8. Ronde | 12.09.2021 | CF América | - | Mazatlán FC | 2:0 | ||||
| 9. Ronde | 19.09.2021 | Mazatlán FC | - | Pumas UNAM | 2:2 | |
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| 11. Ronde | 29.09.2021 | Mazatlán FC | - | FC Juárez | 3:1 | |
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| 12. Ronde | 03.10.2021 | Santos Laguna | - | Mazatlán FC | 1:0 | ||||
| 13. Ronde | 16.10.2021 | Mazatlán FC | - | Atlas Guadalajara | 1:0 | |
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| 15. Ronde | 23.10.2021 | Mazatlán FC | - | Gallos Blancos | 2:1 | |
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| 16. Ronde | 30.10.2021 | Club Necaxa | - | Mazatlán FC | 2:1 | |
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| 17. Ronde | 06.11.2021 | Mazatlán FC | - | Deportivo Guadalajara | 0:1 |
Brazilië
Mexico 