| 1. Ronde | 17.02.2022 | Cobreloa | - | San Luis | 2:1 | ||||
| 2. Ronde | 23.02.2022 | San Luis | - | CD Magallanes | 0:2 | ||||
| 4. Ronde | 10.03.2022 | San Luis | - | Santiago Wanderers | 1:1 | ||||
| 5. Ronde | 17.03.2022 | San Luis | - | Santiago Morning | 1:2 | ||||
| 6. Ronde | 23.03.2022 | Rangers | - | San Luis | 2:3 | ||||
| 7. Ronde | 03.04.2022 | San Luis | - | Deportes Copiapó | 0:0 | ||||
| 8. Ronde | 12.04.2022 | Unión San Felipe | - | San Luis | 2:0 |  |
|||
| 10. Ronde | 22.04.2022 | Puerto Montt | - | San Luis | 1:1 | ||||
| 13. Ronde | 07.05.2022 | Deportes Iquique | - | San Luis | 1:1 | ||||
| 14. Ronde | 13.05.2022 | San Luis | - | Fernández Vial | 0:0 | ||||
| 15. Ronde | 18.05.2022 | Santa Cruz | - | San Luis | 2:0 | ||||
| 16. Ronde | 24.05.2022 | Recoleta | - | San Luis | 2:3 | ||||
| 17. Ronde | 01.06.2022 | San Luis | - | Universidad de Concepción | 0:2 | ||||
| 20. Ronde | 16.07.2022 | San Luis | - | Barnechea | 1:0 | ||||
| 21. Ronde | 26.07.2022 | Santiago Wanderers | - | San Luis | 1:2 | ||||
| 22. Ronde | 01.08.2022 | Santiago Morning | - | San Luis | 1:0 | ||||
| 30. Ronde | 04.10.2022 | San Luis | - | Deportes Iquique | 0:0 | ||||
| 32. Ronde | 16.10.2022 | San Luis | - | Santa Cruz | 0:0 | ||||
| 33. Ronde | 24.10.2022 | San Luis | - | Recoleta | 2:1 |
Chili