| 1. Ronde | 23.07.2018 | Santos Laguna | - | Lobos BUAP | 2:1 | ||||
| 2. Ronde | 28.07.2018 | Monarcas Morelia | - | Santos Laguna | 3:1 | ||||
| 3. Ronde | 06.08.2018 | Santos Laguna | - | Puebla FC | 2:0 |  |
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| 4. Ronde | 13.08.2018 | Deportivo Guadalajara | - | Santos Laguna | 1:2 | ||||
| 9. Ronde | 16.09.2018 | Santos Laguna | - | Club León | 3:0 | ||||
| 11. Ronde | 30.09.2018 | Club Necaxa | - | Santos Laguna | 0:1 | ||||
| 12. Ronde | 06.10.2018 | Santos Laguna | - | Atlas Guadalajara | 3:1 | ||||
| 13. Ronde | 21.10.2018 | CF Pachuca | - | Santos Laguna | 1:1 | ||||
| 15. Ronde | 04.11.2018 | Gallos Blancos | - | Santos Laguna | 2:1 | ||||
| 16. Ronde | 12.11.2018 | Santos Laguna | - | CF América | 1:1 | ||||
| 17. Ronde | 25.11.2018 | Pumas UNAM | - | Santos Laguna | 1:1 |
Mexico