| 1. Ronde | 09.01.2022 | Cruz Azul | - | Club Tijuana | 2:0 |  |
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| 2. Ronde | 16.01.2022 | Cruz Azul | - | FC Juárez | 1:0 | |
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| 3. Ronde | 23.01.2022 | CF Monterrey | - | Cruz Azul | 2:2 | ||||
| 4. Ronde | 08.02.2022 | Club León | - | Cruz Azul | 0:1 | ||||
| 5. Ronde | 13.02.2022 | Cruz Azul | - | Club Necaxa | 1:2 | ||||
| 6. Ronde | 21.02.2022 | Deportivo Toluca | - | Cruz Azul | 1:4 | |
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| 7. Ronde | 28.02.2022 | Cruz Azul | - | Santos Laguna | 1:2 | ||||
| 8. Ronde | 03.03.2022 | UANL Tigres | - | Cruz Azul | 2:2 | ||||
| 9. Ronde | 06.03.2022 | Cruz Azul | - | Puebla FC | 1:3 | ||||
| 10. Ronde | 13.03.2022 | Cruz Azul | - | Pumas UNAM | 2:1 | ||||
| 11. Ronde | 20.03.2022 | CF Pachuca | - | Cruz Azul | 1:0 | |
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| 13. Ronde | 09.04.2022 | Mazatlán FC | - | Cruz Azul | 1:1 |
Mexico