| 1. Ronde | 23.07.2022 | Sporting San Miguelito | - | Alianza | 0:1 | ||||
| 2. Ronde | 31.07.2022 | Plaza Amador | - | Sporting San Miguelito | 1:1 | ||||
| 3. Ronde | 08.08.2022 | Sporting San Miguelito | - | Árabe Unido | 0:0 | ||||
| 4. Ronde | 11.08.2022 | Sporting San Miguelito | - | Tauro FC | 3:1 | ||||
| 6. Ronde | 21.08.2022 | Sporting San Miguelito | - | UD Universitario | 2:2 | ||||
| 7. Ronde | 28.08.2022 | Herrera FC | - | Sporting San Miguelito | 0:0 | ||||
| 8. Ronde | 03.09.2022 | Sporting San Miguelito | - | Veraguas United | 3:2 |  |
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| 9. Ronde | 12.09.2022 | Sporting San Miguelito | - | San Francisco FC | 2:1 | ||||
| 10. Ronde | 18.09.2022 | Atlético Chiriquí | - | Sporting San Miguelito | 0:0 | |
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| 11. Ronde | 24.09.2022 | Independiente de La Chorrera | - | Sporting San Miguelito | 0:2 | |
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| 13. Ronde | 02.10.2022 | Sporting San Miguelito | - | Plaza Amador | 1:1 | ||||
| 14. Ronde | 08.10.2022 | Árabe Unido | - | Sporting San Miguelito | 1:1 | |
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| 16. Ronde | 22.10.2022 | Sporting San Miguelito | - | Potros del Este | 3:2 |
Panama