| 6. Ronde | 21.08.2021 | Club León [U18] | - | Santos Laguna [U18] | 3:1 |  |
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| 7. Ronde | 29.08.2021 | Santos Laguna [U18] | - | FC Juárez [U18] | 0:0 |  |
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| 8. Ronde | 10.09.2021 | Club Tijuana [U18] | - | Santos Laguna [U18] | 3:0 | ||||
| 14. Ronde | 15.09.2021 | CF América [U18] | - | Santos Laguna [U18] | 0:1 | ||||
| 9. Ronde | 19.09.2021 | Santos Laguna [U18] | - | Puebla FC [U18] | 5:1 | ||||
| 10. Ronde | 26.09.2021 | Santos Laguna [U18] | - | CF Monterrey [U18] | 2:0 | ||||
| 12. Ronde | 02.10.2021 | Santos Laguna [U18] | - | Mazatlán FC [U18] | 3:0 | ||||
| 13. Ronde | 16.10.2021 | CF Pachuca [U18] | - | Santos Laguna [U18] | 0:1 | ||||
| 15. Ronde | 24.10.2021 | Santos Laguna [U18] | - | Deportivo Toluca [U18] | 3:1 | ||||
| 16. Ronde | 30.10.2021 | Gallos Blancos [U18] | - | Santos Laguna [U18] | 1:1 | ||||
| 11. Ronde | 04.11.2021 | Pumas UNAM [U18] | - | Santos Laguna [U18] | 0:1 | |
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| 17. Ronde | 07.11.2021 | Santos Laguna [U18] | - | Atlético San Luis [U18] | 6:1 |
Mexico