| 2. Ronde | 15.01.2022 | Cruz Azul [U20] | - | FC Juárez [U20] | 0:0 | ||||
| 3. Ronde | 22.01.2022 | CF Monterrey [U20] | - | Cruz Azul [U20] | 2:2 |  |
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| 5. Ronde | 12.02.2022 | Cruz Azul [U20] | - | Club Necaxa [U20] | 0:1 | ||||
| 11. Ronde | 19.03.2022 | CF Pachuca [U20] | - | Cruz Azul [U20] | 1:0 |  |
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| 13. Ronde | 08.04.2022 | Mazatlán FC [U20] | - | Cruz Azul [U20] | 0:0 | ||||
| 15. Ronde | 21.04.2022 | Gallos Blancos [U20] | - | Cruz Azul [U20] | 1:3 | |
Mexico