| 2. Ronde | 16.01.2021 | Cruz Azul [U20] | - | Puebla FC [U20] | 1:0 | ||||
| 3. Ronde | 22.01.2021 | Puebla FC [U20] | - | Club Tijuana [U20] | 0:2 | ||||
| 11. Ronde | 12.03.2021 | Puebla FC [U20] | - | Atlas Guadalajara [U20] | 0:5 | ||||
| 12. Ronde | 21.03.2021 | Deportivo Toluca [U20] | - | Puebla FC [U20] | 1:2 |  |
 |
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| 1. Ronde | 27.03.2021 | Puebla FC [U20] | - | Deportivo Guadalajara [U20] | 2:4 | ||||
| 15. Ronde | 17.04.2021 | Atlético San Luis [U20] | - | Puebla FC [U20] | 5:3 | ||||
| 16. Ronde | 23.04.2021 | Puebla FC [U20] | - | Pumas UNAM [U20] | 3:2 |
Mexico