| 1. Ronde | 08.01.2022 | Club Tijuana [] | - | Club León [] | 3:2 | ||||
| 2. Ronde | 15.01.2022 | Atlas Guadalajara [] | - | Club Tijuana [] | 1:2 | ||||
| 3. Ronde | 22.01.2022 | Club Tijuana [] | - | Atlético San Luis [] | 5:0 | ||||
| 4. Ronde | 29.01.2022 | UANL Tigres [] | - | Club Tijuana [] | 2:0 | ||||
| 5. Ronde | 05.02.2022 | Club Tijuana [] | - | Deportivo Guadalajara [] | 1:2 | ||||
| 11. Ronde | 19.03.2022 | Deportivo Guadalajara [] | - | Club Tijuana [] | 3:0 | ||||
| 12. Ronde | 26.03.2022 | Club Tijuana [] | - | UANL Tigres [] | 3:1 | ||||
| 17. Ronde | 30.04.2022 | Club Tijuana [] | - | Mazatlán FC [] | 4:0 | ||||
| 18. Ronde | 07.05.2022 | CF Monterrey [] | - | Club Tijuana [] | 1:0 |
Mexico