| 3. Ronde | 23.01.2022 | Santos Laguna [U18] | - | Club Necaxa [U18] | 1:2 | ||||
| 4. Ronde | 06.02.2022 | Atlas Guadalajara [U18] | - | Santos Laguna [U18] | 2:1 | ||||
| 5. Ronde | 12.02.2022 | Santos Laguna [U18] | - | CF América [U18] | 2:2 | ||||
| 6. Ronde | 18.02.2022 | FC Juárez [U18] | - | Santos Laguna [U18] | 0:1 | ||||
| 7. Ronde | 27.02.2022 | Cruz Azul [U18] | - | Santos Laguna [U18] | 1:2 |  |
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| 8. Ronde | 02.03.2022 | Santos Laguna [U18] | - | Pumas UNAM [U18] | 0:0 | ||||
| 9. Ronde | 05.03.2022 | Deportivo Guadalajara [U18] | - | Santos Laguna [U18] | 1:1 | ||||
| 10. Ronde | 12.03.2022 | Santos Laguna [U18] | - | Club Tijuana [U18] | 4:0 | ||||
| 11. Ronde | 18.03.2022 | Puebla FC [U18] | - | Santos Laguna [U18] | 2:2 | ||||
| 13. Ronde | 26.03.2022 | CF Monterrey [U18] | - | Santos Laguna [U18] | 1:2 | ||||
| 12. Ronde | 03.04.2022 | Santos Laguna [U18] | - | CF Pachuca [U18] | 3:1 | ||||
| 14. Ronde | 16.04.2022 | Santos Laguna [U18] | - | Gallos Blancos [U18] | 3:0 | |
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| 15. Ronde | 19.04.2022 | Mazatlán FC [U18] | - | Santos Laguna [U18] | 1:2 | ||||
| 16. Ronde | 24.04.2022 | Santos Laguna [U18] | - | Club León [U18] | 2:3 | ||||
| 17. Ronde | 01.05.2022 | Atlético San Luis [U18] | - | Santos Laguna [U18] | 0:1 |
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