| 3. Ronde | 05.07.2022 | Santos Laguna [U20] | - | Deportivo Guadalajara [U20] | 1:0 | ||||
| 1. Ronde | 03.08.2022 | Santos Laguna [U20] | - | CF Monterrey [U20] | 2:1 | ||||
| 9. Ronde | 18.08.2022 | Santos Laguna [U20] | - | Club León [U20] | 2:3 | ||||
| 16. Ronde | 26.08.2022 | Club Tijuana [U20] | - | Santos Laguna [U20] | 1:1 | ||||
| 11. Ronde | 28.08.2022 | Santos Laguna [U20] | - | Atlético San Luis [U20] | 7:2 | ||||
| 13. Ronde | 06.09.2022 | Santos Laguna [U20] | - | Club Necaxa [U20] | 3:2 | ||||
| 5. Ronde | 14.09.2022 | CF América [U20] | - | Santos Laguna [U20] | 1:0 | ||||
| 4. Ronde | 22.09.2022 | Deportivo Toluca [U20] | - | Santos Laguna [U20] | 1:0 |  |
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