| 1. Ronde | 07.01.2022 | Atlético San Luis | - | CF Pachuca | 0:2 | ||||
| 2. Ronde | 17.01.2022 | CF Pachuca | - | Deportivo Guadalajara | 2:1 |  |
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| 3. Ronde | 23.01.2022 | Club León | - | CF Pachuca | 2:1 | |
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| 4. Ronde | 06.02.2022 | Club Necaxa | - | CF Pachuca | 1:3 | ||||
| 5. Ronde | 15.02.2022 | CF Pachuca | - | Gallos Blancos | 2:2 | ||||
| 6. Ronde | 20.02.2022 | CF América | - | CF Pachuca | 1:3 | ||||
| 7. Ronde | 25.02.2022 | CF Pachuca | - | Mazatlán FC | 3:1 | ||||
| 8. Ronde | 03.03.2022 | Atlas Guadalajara | - | CF Pachuca | 0:1 | ||||
| 10. Ronde | 13.03.2022 | Deportivo Toluca | - | CF Pachuca | 0:3 | ||||
| 11. Ronde | 20.03.2022 | CF Pachuca | - | Cruz Azul | 1:0 | ||||
| 12. Ronde | 04.04.2022 | Santos Laguna | - | CF Pachuca | 3:1 | ||||
| 9. Ronde | 08.04.2022 | CF Pachuca | - | UANL Tigres | 2:1 | ||||
| 13. Ronde | 12.04.2022 | CF Pachuca | - | Club Tijuana | 0:0 | ||||
| 15. Ronde | 20.04.2022 | CF Pachuca | - | Puebla FC | 1:0 | ||||
| 16. Ronde | 24.04.2022 | CF Pachuca | - | CF Monterrey | 3:0 | ||||
| 17. Ronde | 01.05.2022 | Pumas UNAM | - | CF Pachuca | 2:0 | |
Mexico