| 5. Ronde | 11.09.2021 | Vitória Setúbal [A-jun] | - | Amora FC [A-jun] | 2:2 | ||||
| 6. Ronde | 18.09.2021 | CD Nacional [A-jun] | - | Vitória Setúbal [A-jun] | 3:2 |  |
|||
| 7. Ronde | 25.09.2021 | Vitória Setúbal [A-jun] | - | SL Benfica [A-jun] | 1:1 |  |
|||
| 8. Ronde | 02.10.2021 | Os Belenenses [A-jun] | - | Vitória Setúbal [A-jun] | 1:1 | ||||
| 9. Ronde | 16.10.2021 | Vitória Setúbal [A-jun] | - | UD Vilafranquense [A-jun] | 4:1 | |
|
||
| 10. Ronde | 23.10.2021 | Académica de Coimbra [A-jun] | - | Vitória Setúbal [A-jun] | 1:2 | |
|||
| 11. Ronde | 30.10.2021 | Vitória Setúbal [A-jun] | - | SG Sacavenense [A-jun] | 3:2 | ||||
| 12. Ronde | 06.11.2021 | Vitória Setúbal [A-jun] | - | GD Estoril [A-jun] | 1:1 | ||||
| 13. Ronde | 20.11.2021 | União Leiria [A-jun] | - | Vitória Setúbal [A-jun] | 0:4 | ||||
| 20. Ronde | 15.01.2022 | UD Vilafranquense [A-jun] | - | Vitória Setúbal [A-jun] | 0:1 | |
|||
| 21. Ronde | 22.01.2022 | Vitória Setúbal [A-jun] | - | Académica de Coimbra [A-jun] | 1:1 | |
Portugal