| 1. Ronde | 04.04.2021 | Cobreloa | - | Barnechea | 1:2 | ||||
| 2. Ronde | 18.04.2021 | San Marcos | - | Cobreloa | 0:0 | ||||
| 3. Ronde | 26.04.2021 | Cobreloa | - | Universidad de Concepción | 2:4 | ||||
| 5. Ronde | 10.05.2021 | Unión San Felipe | - | Cobreloa | 0:0 | ||||
| 6. Ronde | 18.05.2021 | Cobreloa | - | Santiago Morning | 2:2 |  |
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| 9. Ronde | 07.06.2021 | CD Magallanes | - | Cobreloa | 2:2 | ||||
| 10. Ronde | 09.07.2021 | Cobreloa | - | Deportes Iquique | 3:2 | ||||
| 11. Ronde | 15.07.2021 | Deportes Copiapó | - | Cobreloa | 0:0 | ||||
| 12. Ronde | 21.07.2021 | Cobreloa | - | Puerto Montt | 2:0 | ||||
| 13. Ronde | 31.07.2021 | Deportes Temuco | - | Cobreloa | 1:0 | ||||
| 14. Ronde | 08.08.2021 | Cobreloa | - | Santa Cruz | 0:1 | ||||
| 16. Ronde | 24.08.2021 | Barnechea | - | Cobreloa | 1:1 | ||||
| 26. Ronde | 16.10.2021 | Cobreloa | - | Deportes Copiapó | 2:0 | ||||
| 7. Ronde | 21.10.2021 | Fernández Vial | - | Cobreloa | 3:2 |  |
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| 27. Ronde | 28.10.2021 | Puerto Montt | - | Cobreloa | 0:0 | |
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| 28. Ronde | 02.11.2021 | Cobreloa | - | Deportes Temuco | 0:2 | ||||
| 29. Ronde | 07.11.2021 | Santa Cruz | - | Cobreloa | 2:2 | ||||
| 30. Ronde | 13.11.2021 | Cobreloa | - | Rangers | 4:1 |  |
Chili