| 1. Ronde | 24.07.2021 | FK Dinamo Makhachkala | - | FK Druzhba | 3:0 | ||||
| 2. Ronde | 01.08.2021 | FK Druzhba | - | Rotor-2 Volgograd | 0:2 | ||||
| 3. Ronde | 07.08.2021 | FK Tuapse | - | FK Druzhba | 3:0 | ||||
| 4. Ronde | 15.08.2021 | FK Druzhba | - | FK SKA Rostov | 1:4 | ||||
| 5. Ronde | 21.08.2021 | Dinamo Stavropol | - | FK Druzhba | 1:2 | ||||
| 6. Ronde | 29.08.2021 | FK Druzhba | - | Chernomorets Novorossisk | 0:1 | ||||
| 7. Ronde | 04.09.2021 | FK Yessentuki | - | FK Druzhba | 2:1 |  |
|||
| 8. Ronde | 08.09.2021 | FK Druzhba | - | FK Biolog Novokubansk | 1:1 |  |
|
||
| 9. Ronde | 13.09.2021 | FK Legion Dynamo Makhachkala | - | FK Druzhba | 1:2 | ||||
| 12. Ronde | 03.10.2021 | FK Druzhba | - | FK Chayka | 0:2 | ||||
| 13. Ronde | 10.10.2021 | Anzhi Makhachkala | - | FK Druzhba | 0:0 | ||||
| 15. Ronde | 23.10.2021 | FK Druzhba | - | Alania-2 Vladikavkaz | 1:1 | |
|||
| 16. Ronde | 31.10.2021 | Kuban-Holding Pavlovskaya | - | FK Druzhba | 3:1 | |
|||
| 17. Ronde | 06.11.2021 | FK Druzhba | - | Forte Taganrog | 1:2 | |
|||
| 19. Ronde | 19.11.2021 | FK Druzhba | - | FK Tuapse | 1:0 | ||||
| 20. Ronde | 06.03.2022 | FK SKA Rostov | - | FK Druzhba | 1:0 | ||||
| 21. Ronde | 06.04.2022 | FK Druzhba | - | Dinamo Stavropol | 4:1 | ||||
| 28. Ronde | 30.04.2022 | FK Chayka | - | FK Druzhba | 3:0 | |
Rusland